Endocrine Abstracts

Thyroid hormone (TH) is one of the key players in modulating cardiovascular function. The hormone increases heart rate and force of contraction by modulating cardiac gene expression, thereby providing a molecular explanation for the clinical correlation between hyperthyroidism and cardiovascular mortality. The talk will present current aspects of cardiovascular function mediated by newly discovered TH metabolites. Recent studies have shown that a single injection of 3-iodo-<sm...

Introduction: So far, only two representatives of thyronamines, namely 3-iodothyronamine (3-T1AM) and the iodine–free thyronamine (T0AM), have been detected in vivo. While intensive research is done on the (patho-) physiological function of 3-T1AM, the physiological role of T0AM is poorly studied. Conflicting data have been reported for the acute cardiac effects of T0AM. This project therefore determined whet...

Thyroid hormones (TH) play a pivotal role in embryonal and postnatal development in vertebrates, hence, their secretion is highly regulated. In clinical practice TSH and free T4 (fT4) are commonly used as the most reliable parameters to evaluate the TH status. But they only represent the TH receptor β driven status of the hypothalamic-pituitary-thyroid axis while organ or tissue specific TH availability may be different. This discrepancy originates in the tissue specific ...